The ideas make me think of some of the work of Ray Peat who has written on the role of steroid hormones with respect to bone density. Eg
“a deficiency of thyroid and progesterone can account for many of these changes. Nencioni and Polvani have observed the onset of progesterone deficiency coinciding with bone loss, and have emphasized the importance of progesterone's antagonism to cortisol.”
These ideas make osteoporosis a metabolic issue to be addressed by looking more broadly than the crude drugs you mention.
Peat also calls attention to the need to reduce the phosphorus/calcium ratio as excess phosphorus has problematic effects as you note. Eg
“For about twenty years it has been clear that the metabolic problems that cause calcium to be lost from bones cause calcium to increase in the soft tissues, such as blood vessels. The role of phosphate in forming calcium phosphate crystals had until recently been assumed to be passive, but some specific "mechanistic" effects have been identified. For example, increased phosphate increases the inflammatory cytokine, osteopontin (Fatherazi, et al., 2009), which in bone is known to activate the process of decalcification, and in arteries is involved in calcification processes (Tousoulis, et al., 2012). In the kidneys, phosphate promotes calcification (Bois and Selye, 1956), and osteopontin, by its activation of inflammatory T-cells, is involved in the development of glomerulonephritis, as well as in inflammatory skin reactions (Yu, et al., 1998). High dietary phosphate increases serum osteopontin, as well as serum phosphate and parathyroid hormone, and increases the formation of tumors in skin (Camalier, et al., 2010). Besides the activation of cells and cell systems, phosphate (like other ions with a high ratio of charge to size, including citrate) can activate viruses (Yamanaka, et al., 1995; Gouvea, et al., 2006). Aromatase, the enzyme that synthesizes estrogen, is an enzyme that's sensitive to the concentration of phosphate (Bellino and Holben, 1989).”
Ray Peat was a fascinating thinker. Increasingly I find parallels with your work. Pear unfortunately didn’t give much attention to exercise - accurately defined or not - yet he certainly was no fan of stressful “aerobics”.
Well, I do care, Ken. Mom, in her 70’s, broke her hip and died within a year. I, now in my ‘70’s have had it bad since my ‘50’s (osteoporosis). I’ve been offered all the drugs, which I refuse. I’ve been doing SuperSlow training since 1999. Yes, I’ve fallen a few times, no, I don’t break anything. Thank you for the outstanding article, and for being a health advocate for us.
Yesterday, I received this by text from Doug Holland who is a former SuperSlow Master from Shreveport and owner of Intelligent Exercise. It is a retext from one of his clients:
"[I took the Prolia] shot a month ago. Never again!!!!!! My back and both hips are still not back to normal after that shot. My fingers so swollen and painful but [now] better. I will never take that shot again. I think that's what screwed up my guts too. All happen at the same time. Hopefully, I can come back [to workout] soon."
Another excellent and important article.
The ideas make me think of some of the work of Ray Peat who has written on the role of steroid hormones with respect to bone density. Eg
“a deficiency of thyroid and progesterone can account for many of these changes. Nencioni and Polvani have observed the onset of progesterone deficiency coinciding with bone loss, and have emphasized the importance of progesterone's antagonism to cortisol.”
From https://raypeat.com/articles/articles/osteoporosis.shtml
These ideas make osteoporosis a metabolic issue to be addressed by looking more broadly than the crude drugs you mention.
Peat also calls attention to the need to reduce the phosphorus/calcium ratio as excess phosphorus has problematic effects as you note. Eg
“For about twenty years it has been clear that the metabolic problems that cause calcium to be lost from bones cause calcium to increase in the soft tissues, such as blood vessels. The role of phosphate in forming calcium phosphate crystals had until recently been assumed to be passive, but some specific "mechanistic" effects have been identified. For example, increased phosphate increases the inflammatory cytokine, osteopontin (Fatherazi, et al., 2009), which in bone is known to activate the process of decalcification, and in arteries is involved in calcification processes (Tousoulis, et al., 2012). In the kidneys, phosphate promotes calcification (Bois and Selye, 1956), and osteopontin, by its activation of inflammatory T-cells, is involved in the development of glomerulonephritis, as well as in inflammatory skin reactions (Yu, et al., 1998). High dietary phosphate increases serum osteopontin, as well as serum phosphate and parathyroid hormone, and increases the formation of tumors in skin (Camalier, et al., 2010). Besides the activation of cells and cell systems, phosphate (like other ions with a high ratio of charge to size, including citrate) can activate viruses (Yamanaka, et al., 1995; Gouvea, et al., 2006). Aromatase, the enzyme that synthesizes estrogen, is an enzyme that's sensitive to the concentration of phosphate (Bellino and Holben, 1989).”
https://raypeat.com/articles/articles/phosphate-activation-aging.shtml
Ray Peat was a fascinating thinker. Increasingly I find parallels with your work. Pear unfortunately didn’t give much attention to exercise - accurately defined or not - yet he certainly was no fan of stressful “aerobics”.
Well, I do care, Ken. Mom, in her 70’s, broke her hip and died within a year. I, now in my ‘70’s have had it bad since my ‘50’s (osteoporosis). I’ve been offered all the drugs, which I refuse. I’ve been doing SuperSlow training since 1999. Yes, I’ve fallen a few times, no, I don’t break anything. Thank you for the outstanding article, and for being a health advocate for us.
Yesterday, I received this by text from Doug Holland who is a former SuperSlow Master from Shreveport and owner of Intelligent Exercise. It is a retext from one of his clients:
"[I took the Prolia] shot a month ago. Never again!!!!!! My back and both hips are still not back to normal after that shot. My fingers so swollen and painful but [now] better. I will never take that shot again. I think that's what screwed up my guts too. All happen at the same time. Hopefully, I can come back [to workout] soon."
Spectacular article!
Have you discussed your concerns about bone scanning technology with engineers who work on the designs?
I’d think that would be more productive than speaking to doctors.
Thank you for this Ken!
For years I’ve searched in vain for a complete osteoporosis article for our SuperSlow clients. The search is over. This is it 🙏🏼.
Just another criminal "specialty"... thanks but no thanks Rockefeller and the rest of you Master Manipulator tapeworm parasites.
Thanks for another good job my friend! 👌 𝙈𝙪𝙘𝙝 𝙇𝙤𝙫𝙚 ♡ 𝙉𝙤 𝙁𝙚𝙖𝙧 MLNF🔥🦅